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| Status |
Public on Jun 25, 2010 |
| Title |
Genome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
STAT6 is a major transcription factor driving the polarization of Th2 cells in response to IL-4. STAT6 is phosphorylated by Jak1 and Jak3 kinases at the IL-4 receptor, after which phosphorylated STAT6 forms a homodimer and translocates into the nucleus. There STAT6 binds to specific DNA sequences, regulating the transcription of its target genes. Here we have analyzed on a genome wide level the STAT6 binding sites, after 1h and 4h of IL-4 induction, in naive human CD4+ T cells.
Keywords: SRA
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| Overall design |
Altogether 5 samples from 1 biological replicate were analyzed. Activated and IL-4 treated samples were compared to only activated or untreated samples to identify unique STAT6 binding sites after IL-4 induction.
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| Contributor(s) |
Elo L, Järvenpää H, Tuomela S, Raghav S, Ahlfors H, Gupta B, Tahvanainen J, Lund R, Kirsti L, Harri L, Rasool O, Oresic M, Rao K, Aittokallio T, Lahesmaa R, Hawkins D |
| Citation(s) |
20620947, 24349258 |
| Submission date |
Aug 27, 2009 |
| Last update date |
Aug 08, 2019 |
| Contact name |
Henna Kallionpää |
| E-mail(s) |
henna.kallionpaa@btk.fi
|
| Phone |
+358-2-333-8001
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| Organization name |
University of Turku
|
| Department |
Turku Centre for Biotechnology
|
| Lab |
Riitta Lahesmaa
|
| Street address |
P.O. Box 123
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| City |
Turku |
| ZIP/Postal code |
FIN-20521 |
| Country |
Finland |
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| Platforms (1) |
| GPL9115 |
Illumina Genome Analyzer II (Homo sapiens) |
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| Samples (5)
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| This SubSeries is part of SuperSeries: |
| GSE18017 |
Stat6 mediated regulation of transcription to initiate Th2 program in human T cells |
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| Relations |
| SRA |
SRP002282 |
| BioProject |
PRJNA123545 |
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