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Series GSE178708 Query DataSets for GSE178708
Status Public on May 10, 2022
Title Gene set enrichment analysis of basal and in vitro irradiation differentiates breast cancer patients with late skin radiotherapy toxicity
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Radiation-induced late effects remain a common cause of morbidity amongst cancer survivors.
The purpose of this study was to investigate the molecular basis underlying the radiotherapy-induced late skin toxicity in breast cancer patients who were previously assessed for radiation-induced lymphocyte apoptosis (RILA).
 
Overall design Peripheral blood mononuclear blood cells of 10 patients with severe skin late complications from radiotherapy and 10 patients without symptoms were mock-irradiated or irradiated with 8-Gy X-rays. The 48-h radiation response was analysed by gene expression profiling with Affymetrix microarrays Human Exon 1.0 ST array.Gene set enrichment analysis was performed to identify differentially expressed biological processes.
 
Contributor(s) Aguado-Flor E, Guitérrez-Enríquez S
Citation(s) 35686103
Submission date Jun 22, 2021
Last update date Jun 24, 2022
Contact name Ester Aguado-Flor
Organization name Vall Hebron Institute of Oncology (VHIO)
Lab 3.04B
Street address c/Natzaret, 115-117
City Barcelona
State/province Barcelona
ZIP/Postal code 08035
Country Spain
 
Platforms (1)
GPL5175 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]
Samples (40)
GSM5396338 1SP _no toxicity_irradiated
GSM5396339 1SP_no toxicity_non-irradiated
GSM5396340 2SP _no toxicity_irradiated
Relations
BioProject PRJNA740045

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Supplementary data files not provided
Processed data included within Sample table

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