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| Status |
Public on Oct 04, 2022 |
| Title |
A novel oncogenic enhancer of estrogen receptor positive breast cancer |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
To understand the regulatory landscape of oncogene c-Myc in breast cancer, two epigenetic hallmarks of open chromatin, consisting of H3K4me1 and H3K27ac, were investigated by ChIP-seq in distinct types of human breast cancer cells (estrogen receptor positive MCF-7 and triple-negative MDA-MB-231), respectively. By visualizing the ChIP-seq at c-Myc locus, we noticed that the H3K4me1 and H3K27ac signals were enriched remarkably upstream ~65 kb of c-Myc in MCF-7 cells but not in MDA-MB-231 cells. The results indicated that c-Myc may be regulted by an enhancer located upstream ~65 kb.
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| Overall design |
ChIP-Seq data from MCF-7 and MDA-MB-231 cells
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| |
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| Contributor(s) |
Bao C, Duan J, Xie Y, Lu W |
| Citation(s) |
36159594 |
| Submission date |
Jul 14, 2021 |
| Last update date |
Oct 05, 2022 |
| Contact name |
Wanliang Lu |
| E-mail(s) |
luwl@bjmu.edu.cn
|
| Organization name |
Peking University
|
| Street address |
No.38 Xueyuan Road, Haidian District
|
| City |
Beijing |
| ZIP/Postal code |
100191 |
| Country |
China |
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| Platforms (1) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA746485 |
| SRA |
SRP328297 |
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