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| Status |
Public on Nov 08, 2021 |
| Title |
Indoleamine 2,3-dioxygenase cannot inhibit Chlamydia trachomatis growth in HL-60 human neutrophil granulocytes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Neutrophil granulocytes are the major cells involved in the Chlamydia trachomatis (C.trachomatis)-mediated inflammation and histopathology. A key gene in human intracellular antichlamydial defense is the tryptophan degrading enzyme indoleamine 2,3-dioxygenase (IDO), which limits the growth of the tryptophan auxotroph Chlamydia. Despite its importance, the role of IDO in the intracellular defense against Chlamydia in neutrophils has not yet been characterized.
Affymetrix microarrays were used to obtain global gene expression data for monitoring the effect of C. trachomatis serovar D infection on the transcriptome of human neutrophil granulocytes.
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| Overall design |
Three replicates of C. trachomatis-infected HL-60 samples were compared to three replicates of uninfected control HL-60 samples.
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| Contributor(s) |
Virok DP, Tömösi F, Varga-Bogdanov A, Poliska S, Bruszel B, Cseh Z, Kokai D, Paróczai D, Endresz V, Janaky T, Burián K |
| Citation(s) |
34819931 |
| Submission date |
Jul 16, 2021 |
| Last update date |
Dec 09, 2021 |
| Contact name |
Szilard Poliska |
| E-mail(s) |
poliska@dote.hu
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| Phone |
+3652416432
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| Organization name |
University of Debrecen
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| Department |
Biochemistry and Molecular Biology
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| Lab |
Nuclear Hormone Receptor Research Laboratory
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| Street address |
Egyetem ter 1.
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| City |
Debrecen |
| ZIP/Postal code |
H-4012 |
| Country |
Hungary |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (6)
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| GSM5456507 |
HL-60 cells, uninfected control replicate 1 |
| GSM5456508 |
HL-60 cells, uninfected control replicate 2 |
| GSM5456509 |
HL-60 cells, uninfected control replicate 3 |
| GSM5456510 |
HL-60 cells, C. trachomatis-infected replicate 1 |
| GSM5456511 |
HL-60 cells, C. trachomatis-infected replicate 2 |
| GSM5456512 |
HL-60 cells, C. trachomatis-infected replicate 3 |
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| Relations |
| BioProject |
PRJNA747175 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE180238_RAW.tar |
13.5 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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