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| Status |
Public on May 15, 2024 |
| Title |
SOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Triple-negative breast cancer (TNBC) has a relatively aggressive biological behavior and poor outcome. Our published study showed that PAI-1 could induce the migration and metastasis of TNBC cells. However, the underlying mechanism by which PAI-1 regulates TNBC metastasis has not been addressed. Using microarray analysis of lncRNA expression profiles, we identified a lncRNA SOX2-OT, which is by induced by PAI-1 and could function as an oncogenic lncRNA in TNBC.
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| Overall design |
We treated MDA-MB-231 cells with or without recombinant human PAI-1 or PAI-1 small-molecule inhibitor PAI-039, then used microarray analysis to obtain the lncRNAs expression profiles. Biological replicates: 3 control replicates, 3 transfected replicates.
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| Contributor(s) |
Zhang W, Guan X |
| Citation(s) |
34997317 |
| |
| Submission date |
Jul 30, 2021 |
| Last update date |
May 16, 2024 |
| Contact name |
Wenwen Zhang |
| Organization name |
Nanjing Medical University
|
| Street address |
68 Changle Road
|
| City |
Nanjing |
| State/province |
Jiangsu |
| ZIP/Postal code |
210006 |
| Country |
China |
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| Platforms (1) |
| GPL23646 |
Phalanx Human lncRNA OneArray v1_mRNA (Agilent-074432) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA751053 |
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