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| Status |
Public on Jan 12, 2022 |
| Title |
Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Our study reveals that while antiestrogen therapies effectively limit tumor growth in ER-positive breast cancers, they also trigger a transcriptional program that favors immune evasion.
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| |
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| Overall design |
Study of differential gene expression among wt and CSK k.o. MCF-7 breast cancer cells cultured in DMEM or Fulvestrant
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| |
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| Contributor(s) |
Hühn D, Marti-Rodrigo P, Mouron S, Hansel C, Tschapalda K, Porebski B, Häggblad M, Lidemalm L, Quintela-Fandino MA, Carreras-Puigvert J, Fernandez-Capetillo O |
| Citation(s) |
34392603 |
| Submission date |
Aug 11, 2021 |
| Last update date |
Jan 12, 2022 |
| Contact name |
Anastasios Erik Damdimopoulos |
| Organization name |
Karolinska Institute
|
| Department |
Department of Biosciences and Nutrition
|
| Lab |
Bioinformatics and Expression Analysis Core Facility
|
| Street address |
Hälsovägen 7c
|
| City |
Stockholm |
| State/province |
Huddinge |
| ZIP/Postal code |
141 83 |
| Country |
Sweden |
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| Platforms (1) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA753846 |
| SRA |
SRP332109 |
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