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| Status |
Public on Sep 30, 2021 |
| Title |
Penetrating ballistic brain injury produces acute alterations in sleep and circadian-related genes in the rodent cortex: A preliminary study |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We performed transcriptional profiling in an established rodent model of penetrating ballistic brain injury (PBBI) in conjunction with continuous sleep pattern recording of the first 24 hours after injury. 12 adult male Sprague-Daley rats that were randomized to PBBI (n=6) or sham (n=6) groups, animals received a right unilateral frontal PBBI, then were sacrificed after 24 hours of EGG/EMG recording. Brains were harvested, underwent sectioning and cortical tissue samples were stored. RNA were isolated from tissue samples.
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| Overall design |
RNA-seq of rats after 24 hours: sham and penetrating ballistic brain injury. This dataset includes samples from 11 mice (PBBI (n=6), sham (n=5)).
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| Contributor(s) |
Blaze J, Wang Z, Haghighi F |
| Citation(s) |
34777213 |
| Submission date |
Aug 18, 2021 |
| Last update date |
Nov 18, 2021 |
| Contact name |
Fatemeh Haghighi |
| E-mail(s) |
fatemeh.haghighi@mssm.edu
|
| Organization name |
Icahn School of Medicine at Mount Sinai
|
| Department |
Neuroscience
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| Lab |
Haghighi Lab
|
| Street address |
1425 Madison Ave, 9-20D
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10029 |
| Country |
USA |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA756004 |
| SRA |
SRP333118 |
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