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| Status |
Public on Dec 07, 2021 |
| Title |
The cardiac glycoside deslanoside imposes an anticancer effect on prostate cancer involving multiple signaling pathways |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Prostate cancer (PCa) is a leading cause of cancer-related deaths among men worldwide, and advanced prostate cancers are mostly incurable. It is urgently needed to find new therapeutic options. Deslanoside is a cardiac glycoside, the efficacy of which on cancers has never been reported. In this study, we investigated the effects of deslanoside on advanced PCa for the first time. RNA-sequencing results identified 141 differentially expressed mRNAs in deslanoside-treated PCa cells compared to untreated cells, which were significantly enriched in the cancer-associated pathways, including necroptosis, MAPK signaling pathway, NOD-like receptor signaling pathway, focal adhesion, small lung cancer, GnRH signaling pathway, IL-17 signaling pathway, TNF signaling pathway and apoptosis. Kaplan-Meier plotter analysis identified the effects of 11 deslanoside-influenced genes on recurrence-free survival and 4 genes on overall survival. Taken together, these results repurpose that a novel utilization of deslanoside in prostate cancer, which exerts profound inhibitory effects on advanced PCa progression.
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| Overall design |
Prostate cancer mRNA profiles of DMSO-treated and Deslanoside-treated cells
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| Contributor(s) |
Huang Q, Liu M, Jun A, Li X |
| Citation(s) |
34830961 |
| Submission date |
Sep 17, 2021 |
| Last update date |
Dec 07, 2021 |
| Contact name |
Jin-Tang and Dong |
| E-mail(s) |
dongjt@sustech.edu.cn
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| Phone |
86-755-88018032
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| Organization name |
Southern University of Science and Technology
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| Street address |
1088 Xueyuan Blvd., Research Building 2B
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| City |
Shenzhen |
| State/province |
Guangdong |
| ZIP/Postal code |
518055 |
| Country |
China |
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| Platforms (1) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA764252 |
| SRA |
SRP337689 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE184380_gene-FPKM-Counts-expression.txt.gz |
2.1 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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