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| Status |
Public on Sep 14, 2022 |
| Title |
Effect of inactivation of Mst1 and Mst2 in the mouse adrenal cortex |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The Hippo Pathway has been found to play an important role in adrenal gland development and maintenance in mice.
In this study, we further explored the role of the Hippo pathway in the adrenal gland using a transgenic mouse model where we knocked out the upstream kinases of the pathway, Mst1 and Mst2.
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| Overall design |
Nr5a1-Cre and Mst1(flox/flox);Mst2(flox/flox) were selectively bred over generations to obtain Mst1(flox/flox);Mst2(flox/flox);Nr5a1-Cre mutant mice. Controls are considered the Mst1(flox/flox);Mst2(flox/flox) mice. At 2 months of age, mice were dissected and adrenal glands were isolated and conserved at -80°C.
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| Contributor(s) |
Abou Nader N, Boyer A |
| Citation(s) |
36405866 |
| Submission date |
Oct 05, 2021 |
| Last update date |
Dec 01, 2022 |
| Contact name |
Nour Abou Nader |
| E-mail(s) |
nour.abou.nader@umontreal.ca
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| Phone |
4502090139
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| Organization name |
Université de Montréal
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| Department |
Biomédecine vétérinaire
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| Street address |
3200 rue sicotte
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| City |
Saint-Hyacinthe |
| State/province |
Québec |
| ZIP/Postal code |
J2S 2M2 |
| Country |
Canada |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA768884 |
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