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| Status |
Public on Nov 01, 2011 |
| Title |
Transcriptional Profile of Aging in Healthy Human Skin |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Gene expression changes were assessed from the non sun-exposed skin of the lower back of 98 healthy males aged 19-86. We show that contrary to previous thought, genome wide transcriptional activity does not display an exclusively linear correlation with ageing, but rather, in human skin, undergoes a period of significant transient change between 30 and 45 years of age. The identified transient transcriptional changes suggest a period of heightened metabolic activity and cellular damage mediated primarily through the actions of TP53 (tumour protein 53) and TNF (tumour necrosis factor). We also identified a subgroup of the population characterised by increased expression of a large group of hair follicle genes that correlates strongly with a younger age of onset and increasing severity of androgenetic alopecia.
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| Overall design |
Skin was collected from the lower back at the level of the belt, aproximately 5cm lateral to midline from healthy males, (defined as; non-smoking, no hospital admissions in the previous 5 years, no significant medical conditions or medications). Each sample was individually hybridised to an exon 1.0 ST array.
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| Contributor(s) |
Haustead DJ, Fear M |
| Citation(s) |
27229172 |
| Submission date |
Nov 03, 2009 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Daniel J Haustead |
| E-mail(s) |
daniel.haustead@health.wa.gov.au
|
| Phone |
+61 405 094 915
|
| Organization name |
University Of Western Australia
|
| Department |
Surgery
|
| Lab |
Burn Injury Research Unit
|
| Street address |
35 stirling highway (M317)
|
| City |
Perth |
| State/province |
WA |
| ZIP/Postal code |
6009 |
| Country |
Australia |
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| Platforms (1) |
| GPL5175 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version] |
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| Samples (98)
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| Relations |
| BioProject |
PRJNA121133 |
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