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| Status |
Public on Jan 01, 2022 |
| Title |
circRNA expression in human myometrium during labor |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
The maintenance of coordinated powerful episodic contractions of the uterus is the crucial factor for normal labor. The uterine contractility is gradually enhanced with the progression of labor, which is related to the gene expression of myometrium, competing endogenous RNA (ceRNA) can also regulate the gene expression. To better understand the role of ceRNA network in labor, transcriptome sequencing was performed on the myometrium of 17 parturients at different labor duration. Furthermore, an correlated analysis was performed to identify mRNA, long non-coding RNA (lncRNA), circular RNA (circRNA), and microRNA (miRNA) which correlated with their expression levels and labor duration. Then, targeting relationships between mRNAs, lncRNAs, circRNAs and miRNAs were predicted, and the ceRNA regulatory network was established.This analysis identified 934 RNAs positively correlated with labor duration (859 mRNAs, 28 lncRNAs, 45 circRNAs, and 2 miRNAs) and 153 RNAs negatively correlated with labor duration (122 mRNAs, 28 lncRNAs, and 3 miRNAs).
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| |
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| Overall design |
Examination of human myometrium in labor and not in labor
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| |
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| Contributor(s) |
Chen L, Liu H, Luo Y, Ji K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 15, 2021 |
| Last update date |
Jan 01, 2022 |
| Contact name |
Kaiyuan Ji |
| E-mail(s) |
jky435@smu.edu.cn
|
| Organization name |
Guangzhou Medical University
|
| Department |
Guangzhou Women and Children’s Medical Center
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| Lab |
Department of Obstetrics and Gynecology
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| Street address |
No.9 Jinsui Road, Guangzhou, China
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| City |
Guangzhou |
| ZIP/Postal code |
510623 |
| Country |
China |
| |
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| Platforms (1) |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA780546 |
| SRA |
SRP346214 |
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