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| Status |
Public on Feb 13, 2024 |
| Title |
Long-term effects of Elastase inhibition on human islets at single-cell resolution |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To evaluate the long-term effect of elastase inhibition using telaprevir, sivelestat, or DMSO on human islet cells.
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| |
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| Overall design |
Human islets (N=3) were treated for 24 hours with DMSO, telaprevir (1 and 100 µg/ml), or sivelestat (100 µg/ml) to evaluate the changes in gene expression levels in endocrine and exocrine cells using single-cell RNA-seq (scRNA-seq) procedures.
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| |
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| Contributor(s) |
Basile G, Kulkarni R |
| Citation(s) |
37339634 |
| Submission date |
Dec 08, 2021 |
| Last update date |
Feb 13, 2024 |
| Contact name |
Jonathan M Dreyfuss |
| Organization name |
Joslin Diabetes Center
|
| Department |
Bioinformatics & Biostatistics Core
|
| Street address |
1 Joslin Pl
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA787208 |
| SRA |
SRP349811 |
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