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| Status |
Public on Jun 22, 2022 |
| Title |
Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We revealed that concurrent activation of the Kras and canonical Wnt pathways resulted in formation of ICPN and BilIN, which could develop into biliary cancer.
We found that c-Myc contributed to tumorigenesis, whereas Tgf-β pathway inhibited it.
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| |
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| Overall design |
Hnf1bCreER, Hnf1bCreER;Kras, Hnf1bCreER;Ctnnb1, and Hnf1bCreER;Kras;Ctnnb spheroids were analyzed (n=3/group).
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| Contributor(s) |
Nagao M, Fukuda A |
| Citation(s) |
35247892 |
| Submission date |
Dec 16, 2021 |
| Last update date |
Jun 25, 2022 |
| Contact name |
Munemasa Nagao |
| E-mail(s) |
ds110559@kuhp.kyoto-u.ac.jp
|
| Phone |
81-75-751-4319
|
| Organization name |
Kyoto University Graduate School of Medicine
|
| Department |
Gastroenterology
|
| Street address |
54 Kawaharacho, Shogoin, Sakyoku
|
| City |
Kyoto |
| State/province |
Kyoto |
| ZIP/Postal code |
6068507 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA789569 |
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