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| Status |
Public on Feb 17, 2023 |
| Title |
A druggable signaling hub of choroid plexus immune-secretory function |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Integrated multi-omics investigation of novel rat models of acquired hydrocephalus, Blood or bacteria in CSF trigger similar choroid plexus (ChP) immune-secretory responses, Crosstalk between ChP immune and epithelial cells drives CSF hypersecretion and ventriculomegaly, Repurposed systemic immunomodulators ameliorate acquired hydrocephalus, Identification of a druggable hub of ChP function relevant for multiple neurological diseases.
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| Overall design |
Examine the effect of IVH and LPS on ChP
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| |
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| Contributor(s) |
Kahle KT, Kiziltug E, Mansuri MS, Karimy J, Robert S |
| Citation(s) |
36803604 |
| Submission date |
Jan 03, 2022 |
| Last update date |
May 19, 2023 |
| Contact name |
Kristopher Kahle |
| E-mail(s) |
kahle.kristopher@mgh.harvard.edu
|
| Organization name |
Yale university
|
| Department |
Department of Neurosurgery
|
| Street address |
333 ceder st
|
| City |
new haven |
| State/province |
CT |
| ZIP/Postal code |
06511 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA793868 |
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