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| Status |
Public on Jan 26, 2022 |
| Title |
single-nucleotide resolution sequencing of N6-methyladenine in E. coli genomes and mammalian mitochondrial DNA |
| Organisms |
Escherichia coli; Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
N6-methyladenine (6mA) is a natural DNA modification and functions primarily in restriction-modification (R-M) systems in prokaryotes. Recent studies uncovered the existence and revealed the genome-wide distribution of 6mA in eukaryotes. Specifically, it was reported that 6mA was mainly enriched in mammalian mitochondrial DNA (mtDNA) and could regulate mitochondrial activity. we achieved the genome-wide mapping of 6mA in E. coli genome and mammalian mtDNA at single-nucleotide resolution.
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| Overall design |
Mapping of N6-methyladenine DNA modification in E. coli genomes and mammalian mitochondrial DNA
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| Contributor(s) |
Ma C, Li G, Shao W, Yuan B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 23, 2022 |
| Last update date |
Jan 29, 2022 |
| Contact name |
li gao jie |
| E-mail(s) |
ligj@big.ac.cn
|
| Phone |
18713869581
|
| Organization name |
Beijing Institute of Genomics, Chinese Academy of Sciences
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| Street address |
Building 104, Yard 1, Beichen West Road, Chaoyang District, Beijing
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| City |
北京 |
| State/province |
beijing |
| ZIP/Postal code |
010001 |
| Country |
China |
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| Platforms (2) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL14548 |
Illumina HiSeq 2000 (Escherichia coli) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA799740 |
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