|
| Status |
Public on Aug 11, 2010 |
| Title |
Blood Transcriptional Profiles of TB in South Africa |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The aim of this study was to compare the transcriptional response to TB in regions of different incidence / prevalence.
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| |
|
| Overall design |
Experimental Design: Whole blood collected in tempus tubes from patients with different spectra of TB disease. All patients were sampled prior to the initiation of any antimycobacterial therapy. Active Pulmonary TB: PTB - All patients confirmed by isolation of Mycobacterium Tuberculosis on culture of sputum. Latent TB: LTB - All patients were screened at a tuberculosis clinic. All were positive by Interferon-Gamma Release assay(IGRA); specifically Quantiferon Gold In-Tube Assay (Cellestis, Australia). Latent patients had no clinical, or microbiological evidence of active infection and were asymptomatic. Experimental Variables: Patient group: Active PTB; Latent TB. There are no healthy controls in this dataset as it was being used for validation only. Controls: Latent TB individuals are used as a control for PTB in this dataset since there are few to no unexposed adult controls in Cape Town.
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| |
|
| Citation(s) |
20725040 |
| Submission date |
Dec 12, 2009 |
| Last update date |
Aug 16, 2018 |
| Contact name |
Damien Chaussabel |
| E-mail(s) |
DChaussabel@benaroyaresearch.org
|
| Organization name |
Baylor Institute for Immunology Research
|
| Street address |
3434 Live Oak
|
| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75204 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
|
| Samples (51)
|
|
| This SubSeries is part of SuperSeries: |
| GSE19491 |
Blood Transcriptional Profiles in Human Active and Latent Tuberculosis |
|
| Relations |
| BioProject |
PRJNA123921 |
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