|
| Status |
Public on Jan 30, 2022 |
| Title |
Expression data from HepaRG human progenitor hepatic cells treated with different sources of Vitamin E and wheat germ oil. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
According with the hepatic protection role of Vitamin E (VE), clinical guidelines of gastroenterology societies are now supporting the administration of VE as first line treatment of Non-Alcoholic SteatoHepatitis (NASH).
We used microarrays to detail the transcriptional response obtained by pre-administration to HepaRG cell line of different sources of VE (WGO-VE, nVE and sVE) followed by exposure to oleic acid (OA) to induce conditions of steatosis
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| |
|
| Overall design |
We compared transcriptional response of OA-treated HepaRG for 48 hours with transcriptional response of HepaRG pre-treated with different sources of VE for 24 hrs and subsequent 48 hours of treatment with OA.
|
| Web link |
https://doi.org/10.1016/j.heliyon.2022.e10748
|
| |
|
| Contributor(s) |
Guerrini A, Frammartino T |
| Citation(s) |
36193535 |
| Submission date |
Jan 28, 2022 |
| Last update date |
Oct 17, 2022 |
| Contact name |
Jacopo Lucci |
| E-mail(s) |
jlucci@biostherapy.it
|
| Phone |
+393428018168
|
| Organization name |
Bios-Therapy, Physiological Systems For Health S.p.A
|
| Lab |
Laboratory of system biology
|
| Street address |
Loc. Aboca, 20
|
| City |
Sansepolcro |
| State/province |
Arezzo |
| ZIP/Postal code |
52037 |
| Country |
Italy |
| |
|
| Platforms (1) |
| GPL31262 |
[GO_Screen_hu] Affymetrix human GO_Screen_hu Assay |
|
| Samples (14)
|
| GSM5841806 |
HepaRG cells treated only with oleic acid [OA 1] |
| GSM5841807 |
HepaRG cells treated only with oleic acid [OA 2] |
| GSM5841808 |
HepaRG cells treated only with oleic acid [OA 3] |
| GSM5841809 |
HepaRG cells treated with sVE and OA [sVE_OA 1] |
| GSM5841810 |
HepaRG cells treated with sVE and OA [sVE_OA 2] |
| GSM5841811 |
HepaRG cells treated with sVE and OA [sVE_OA 3] |
| GSM5841812 |
HepaRG cells pre-treated with nVE and OA [nVE_OA 1 ] |
| GSM5841813 |
HepaRG cells pre-treated with nVE and OA [nVE_OA 2] |
| GSM5841814 |
HepaRG cells pre-treated with nVE and OA [nVE_OA 3] |
| GSM5841815 |
HepaRG cells pre-treated with WGO-VE and with OA [WGO-VE_OA 1] |
| GSM5841816 |
HepaRG cells pre-treated with WGO-VE and with OA [WGO-VE_OA 2] |
|
| Relations |
| BioProject |
PRJNA801505 |
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