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| Status |
Public on Dec 09, 2022 |
| Title |
Transcriptome analysis of primary normal fibroblasts and matched cancer associated fibroblasts |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To get an insight into the mechanisms for CAF-supported metastasis in breast cancers, we performed RNA-sequencing (RNA-seq) analysis with seven pairs of primary NFs and CAFs.Gene set variation analysis (GSVA) showed significant upregulated expression of genes enriched with cancer metastasis-associated signaling pathways. Besides, we identified CAF signature genes, which have similar patterns in several of these primary CAFs.
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| Overall design |
The mRNA profiles of seven pairs of primary normal fibroblasts and matched cancer associated fibroblasts
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| Contributor(s) |
Wu X, Li Q, Lv X, Han C |
| Citation(s) |
36438487 |
| Submission date |
Feb 08, 2022 |
| Last update date |
Dec 09, 2022 |
| Contact name |
xudong Wu |
| Organization name |
Tianjin medical university
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| Street address |
Qixiangtai Road
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| City |
Tianjin |
| ZIP/Postal code |
300070 |
| Country |
China |
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| Platforms (2) |
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| Samples (14)
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| This SubSeries is part of SuperSeries: |
| GSE196404 |
Enhancer reprogramming promotes the activation of cancer-associated fibroblasts and breast cancer metastasis |
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| Relations |
| BioProject |
PRJNA804509 |
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