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| Status |
Public on Mar 06, 2022 |
| Title |
RNF186/EPHB2 axis is essential for colorectal tumorigenesis by regulating TNFα signalling in colorectal epithelial cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We provide evidence that the EPHB2-RNF186-TAB2-TAK1 signalling cascade plays an essential role in TNFα-mediated signal transduction in colorectal epithelial cells and the carcinogenesis of CRC, which may provide potential targets for the treatment of colorectal cancer.
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| Overall design |
The differentially expressed genes from control Ls174t cells or RNF186-overexpressed Ls174t cells were analysised by transcriptomes sequence .
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| Contributor(s) |
Wang C, Zhang H, Cui Z, Hu H |
| Citation(s) |
36130827 |
| Submission date |
Mar 03, 2022 |
| Last update date |
Nov 17, 2022 |
| Contact name |
Huazhi Zhang |
| E-mail(s) |
scientsgene@yeah.net
|
| Organization name |
Huazhong University of Science and Technology
|
| Street address |
Luoyu Road
|
| City |
Wuhan |
| ZIP/Postal code |
430000 |
| Country |
China |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA812678 |
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