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| Status |
Public on May 10, 2023 |
| Title |
Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16 [CUT&TAG] |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
We performed multiomic high-throughput sequencing to recapitulated the primary mechanism of mesenchymal stem cells osteogenesis. We analysed the H3K27ac ChIP-seq, BRD4 CUT&Tag and RNA-seq data before and after osteogenesis, and identified super enhancers (SEs) regulated osteogenic identity genes in MSCs.
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| Overall design |
Examination of the BRD4 binding to genome in MSCs
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| Contributor(s) |
Shen H, Xie Z, Wu Y, Yu W |
| Citation missing |
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| Submission date |
Jun 15, 2022 |
| Last update date |
May 12, 2023 |
| Contact name |
Wenhui Yu |
| E-mail(s) |
yuwh5@mail2.sysu.edu.cn
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| Organization name |
The Eighth Affiliated Hospital of Sun Yat-sen University
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| Department |
Department of Orthopedics
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| Street address |
Shennan middle road #3025
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| City |
Shenzhen |
| ZIP/Postal code |
518003 |
| Country |
China |
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| Platforms (2) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE192963 |
Super enhancers orchestrate osteogenesis program through navigation and initiation effects of Brd4 on Zbtb16 |
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| Relations |
| BioProject |
PRJNA849508 |
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