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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Aug 31, 2022 |
| Title |
miRNome and proteome profiling of small extracellular vesicles secreted by human glioblastoma cell lines and primary cancer stem cells. |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
We investigated in parallel the miRNome and proteome of the small EVs (sEVs) released by two different human GBM established cell lines and by GBM primary cancer stem cell (CSC) lines, to explore the role of sEVs in their different tumor behavior and capacities, and to assess whether these different EVs that coexist in the tumor burden are functionally interrelated, and/or may together target distinct cellular pathways that converge on the same biological goals
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| Overall design |
miRNA expression profiling of small extracellular vesicles (sEVs) secreted in the culture medium by two human glioblastoma (GBM) established cell lines, namely U373 MG-Uppsala and U87 MG, and GBM primary cancer stem cell (CSC) lines. Three samples, each in duplicate, were analyzed: U373-sEVs, U87-sEVs and CSC-sEVs.
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| Contributor(s) |
Cifola I, Fratini F, Cardinali B, Palmieri V, Gatti G, Selmi T, Donzelli S, Sacconi A, Cesarini V, Marei HE, Papi M, Blandino G, Cenciarelli C, Falcone G, D’Agnano I |
| Citation(s) |
36009432 |
| Submission date |
Jun 22, 2022 |
| Last update date |
Sep 01, 2022 |
| Contact name |
andrea sacconi |
| Organization name |
regina elena cancer institute
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| Street address |
via elio chianesi
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| City |
rome |
| ZIP/Postal code |
00144 |
| Country |
Italy |
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| Platforms (1) |
| GPL25134 |
Agilent-070156 Human_miRNA_V21.0_Microarray 046064 (miRNA ID version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA851749 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE206675_RAW.tar |
16.9 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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