 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Jul 19, 2022 |
| Title |
A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes [SiHa] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The aim of this study was to construct and validate a prognostic risk model to predict the overall survival (OS) of patients with cervical cancer, providing a reference for individualized clinical treatment that may lead to better clinical outcomes.
HLA-G-driven DEG signature consisting of the eight most important prognostic genes CD46, LGALS9, PGM1, SPRY4, CACNB3, PLIN2, MSMO1, and DAGLB was identified as a key predictor of cervical cancer.
To summarize, we developed and validated a novel prognostic risk model for cervical cancer based on HLA-G-driven DEGs, and the prognostic signature showed great ability in predicting the overall survival of patients with cervical cancer.
|
| |
|
| Overall design |
HLA-G-driven differentially expressed genes (DEGs) were obtained from two cervical carcinoma cell lines, namely, SiHa and HeLa, with stable overexpression of HLA-G by RNA sequencing (RNA-seq).
|
| |
|
| Contributor(s) |
Xu H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 13, 2022 |
| Last update date |
Jul 19, 2022 |
| Contact name |
Hui-Hui Xu |
| E-mail(s) |
xuhh@enzemed.com
|
| Phone |
+86-13757609637
|
| Organization name |
Taizhou Hospital
|
| Street address |
150
|
| City |
Linhai |
| State/province |
Zhejiang province |
| ZIP/Postal code |
317000 |
| Country |
China |
| |
|
| Platforms (1) |
|
| Samples (6)
|
|
| This SubSeries is part of SuperSeries: |
| GSE208119 |
A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes |
|
| Relations |
| BioProject |
PRJNA858421 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE208118_Processed_data_files_SiHa-HLA-G_VS._SiHa_FPKM.csv.gz |
307.0 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...