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| Status |
Public on Mar 23, 2010 |
| Title |
Genome-wide analysis of gene expression profiles in ITNK |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of gene expression profiles in Induced T-to-Natural Killer (ITNK), compared to DN3 parental T cells and IL-2-expanded NK cells (LAK). The hypothesis tested in the present study was that gene expression profiles of ITNK that were derived from DN3 T cells after deletion of Bcl11b were more similar to LAK, rather than DN3 T cells. Results provide important information of the ITNKs, such as canditate genes regulated by Bcl11b, up-regulated important genes expressed in NK cells, and down-regulated T cell genes.
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| |
|
| Overall design |
Total RNA obtained from DN3-derived ITNKs in vitro compared to DN3 parental T cells and LAKs.
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| |
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| Contributor(s) |
Liu P, Li P, Chen X |
| Citation(s) |
20538915 |
| Submission date |
Mar 23, 2010 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Jack Chen |
| Organization name |
NIH
|
| Street address |
SAIC-Frederick Miller Dr
|
| City |
Frederick |
| State/province |
MD |
| ZIP/Postal code |
21702 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA125761 |
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