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| Status |
Public on May 01, 2024 |
| Title |
Next generation sequencing for miRNA profile of blood sample of goiter rat model treated by quemeiteng granule |
| Organism |
Rattus norvegicus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
MicroRNAs play important roles in the regulatory processes of occurrence and progression of goiter. In the present study, whole transcriptome sequencing analysis was applied to investigate the expression profiles of miRNAs. After comparing blood samples of propylthiouracil (PTU)-induced goiter model blood samples and quemeiteng granule (QMTG) treated groups, 1 miRNA was found to be differentially expressed. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to investigate the potential functions of the mRNAs. Our study proved QMTG relieves goiter by suppressing thyroid angiogenesis through miR-217-5p targeting of FGF2 regulating ERK pathway.
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| Overall design |
Examination of miRNA profile in blood sample of six groups.
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| Contributor(s) |
Li Y, Yang W, Wu H |
| Citation missing |
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| Submission date |
Aug 20, 2022 |
| Last update date |
May 01, 2024 |
| Contact name |
Yang Li |
| E-mail(s) |
leeyeungwestchina@outlook.com
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| Organization name |
West China Hospital of Sichuan University
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| Street address |
No.37 Guoxue Alley, Wuhou District,
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| City |
Chengdu |
| ZIP/Postal code |
610000 |
| Country |
China |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA871780 |
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