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Series GSE211748 Query DataSets for GSE211748
Status Public on May 15, 2024
Title Differential dynamic plasma miRNA profiles during the peri-implantation period in patients with different reproductive outcomes following embryo transfer
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary To investigate the differential dynamic plasma miRNA profiles during the peri-implantation period in patients with different reproductive outcomes following embryo transfer. 10 negative pregnancy (NP) patients, 10 biochemical pregnancy loss (BPL) patients, and 10 clinical pregnancy (CP) patients were enrolled for miRNA-seq in this study. Peripheral blood samples were collected at three time-points (ET0, ET11, and ET14) from BPL patients and CP patients, and samples were collected at two time-points (ET0 and ET11) from NP patients. Small RNA libraries were constructed using peripheral plasma RNA. miRNA-seq was used to investigate the differential dynamic peripheral miRNA changes between the three groups during the peri-implantation period.
 
Overall design We prospectively recruited a cohort undergoing embryo transfer (ET). Peripheral llood samples were collected on ET day before ET (ET0), 11 days after ET (ET11), and 14 days (ET14) after ET. The patients were divided into the negative prengancy (NP), biochemical pregnancy loss (BPL), and clinical pregnancy (CP) groups according to serum hCG levels. Ten patients in each group were randomly selected for miRNA-seq.
 
Contributor(s) Zeng H, Shen L, Fu Y, Quan S
Citation(s) 38720272
Submission date Aug 22, 2022
Last update date May 15, 2024
Contact name Hong Zeng
E-mail(s) minizenghong@126.com
Organization name Nanfang Hospital
Street address 1838 North Guangzhou Street
City Guangzhou
State/province Guangdong
ZIP/Postal code 510515
Country China
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (78)
GSM6500571 Plasma miRNA-seq at ET0 of BP YFC-10 [YFC-10-1]
GSM6500572 Plasma miRNA-seq at ET0 of BP YFC-26 [YFC-26-1]
GSM6500573 Plasma miRNA-seq at ET0 of BP YFC-36 [YFC-36-1]
Relations
BioProject PRJNA872004

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Supplementary file Size Download File type/resource
GSE211748_TPM_all_samples.csv.gz 147.1 Kb (ftp)(http) CSV
GSE211748_TPM_and_counts_all_samples.csv.gz 205.0 Kb (ftp)(http) CSV
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