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| Status |
Public on Sep 26, 2022 |
| Title |
Modeling pleomorphic rhabdomyosarcoma in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Here we used Ptch1+/-/ETV7TG/+/- mice with enhanced incidence of RMS to generate a model of pleomorphic RMS driven by haploinsufficiency of the lysosomal sialidase Neu1. These tumors share features and location with human RMS.
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| Overall design |
We compared fourteen tumor samples taken from Neu1+/−/Ptch1+/−/ETV7 TG+/− (NPE) mice with seven tumor samples from Ptch1+/−/ETV7 TG+/− (PE) mice using the Mouse ClariomS array.
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| Contributor(s) |
Machado ER, Downing SM, Finkelstein DB, Neale GA |
| Citation(s) |
36127469 |
| Submission date |
Aug 30, 2022 |
| Last update date |
Oct 04, 2022 |
| Contact name |
Alessandra d'Azzo |
| E-mail(s) |
sandra.dazzo@stjude.org
|
| Phone |
9015952698
|
| Organization name |
St Jude Children's Research Hospital
|
| Department |
Genetics
|
| Lab |
d'Azzo Lab
|
| Street address |
262 Danny Thomas Place
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (21)
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| Relations |
| BioProject |
PRJNA875145 |
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