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| Status |
Public on Apr 13, 2010 |
| Title |
Genes differentially expressed in primary and metastatic liver GISTs. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Although the main cause of gastrointestinal stromal tumor (GIST) is due to gain-of-function mutation of the c-kit gene in the interstitial cells of Cajal, concomitant genetic or epigenetic changes other than c-kit are thought to occur in the development of metastasis.
We used microarrays to identify genes that were up-regulated and down-regulated in the metastatic liver GIST.
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| Overall design |
Three primary gastric GISTs without synchronous or metachronous metastasis and five metastatic liver tumors originated from gastric GIST were utilized for RNA extraction and hybridization on Affymetrix microarrays. No patients had received imatinib therapy before surgery.
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| Contributor(s) |
Setoguchi T, Kikuchi H, Yamamoto M, Gto-Inoue N, Setou M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 12, 2010 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Hirotoshi Kikuchi |
| E-mail(s) |
kikuchih@hama-med.ac.jp
|
| Phone |
+81-53-435-2279
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| Fax |
+81-53-435-2273
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| Organization name |
Hamamatsu University School of Medicine
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| Department |
Second Department of Surgery
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| Street address |
1-20-1 Handayama, Higashi-ku
|
| City |
Hamamatsu |
| ZIP/Postal code |
431-3192 |
| Country |
Japan |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA126323 |
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