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| Status |
Public on Apr 29, 2024 |
| Title |
Single-Cell ATAC+RNAseq from CD34+ cells of a Primary Myelofibrosis patient evolved to secondary Acute Myeloid Leukemia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
To characterize the impact of chromatin remodelers’ mutations in MPN onset and development and identify regulatory elements driving gene expression modulations during disease progression, we performed a single-nucleus RNAseq coupled with single-cell ATACseq experiment on CD34+ cells from the chronic and blast phase of a Primary Myelofibrosis patient.
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| Overall design |
Comparative gene expression and chromatin accessibility profiling analysis of single cell ATAC+RNA-seq data for bone marrow CD34+ cells from during Primary Myelofibrosis (sample1) and after secondary Acute Myeloid Leukemia transformation (sample2).
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| Contributor(s) |
Carretta C, Guglielmelli P, Vannucchi AM, Manfredini R |
| Citation(s) |
37399248 |
| Submission date |
Dec 30, 2022 |
| Last update date |
Apr 30, 2024 |
| Contact name |
Rossella Manfredini |
| E-mail(s) |
rossella.manfredini@unimore.it
|
| Organization name |
University of Modena and Reggio Emilia
|
| Department |
Department of Biomedical, Metabolic and Neural Sciences
|
| Street address |
Via Gottardi 100
|
| City |
Modena |
| ZIP/Postal code |
41125 |
| Country |
Italy |
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| Platforms (1) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA916925 |
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