|
| Status |
Public on Oct 07, 2010 |
| Title |
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
|
| Summary |
We integrate high-resolution copy number data with transcriptional profiles and identify the immunoregulatory genes, PD-L1 and PD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines.
|
| |
|
| Overall design |
DNA copy number alterations were defined in DLBCL and HL cell lines, normalized to healthy donors, by GISTIC analysis of Affymetrix SNP 6.0 single nucleotide polymorphism microarray data. Using this analysis, we identified 9p24 amplification to be over-represented in HL cell lines compared to DLBCL cell lines.
|
| |
|
| Contributor(s) |
Green MR, Monti S, Takeyama K, Shipp MA |
| Citation(s) |
20628145 |
| Submission date |
Jun 08, 2010 |
| Last update date |
Nov 27, 2018 |
| Contact name |
Michael Richard Green |
| E-mail(s) |
michaelr_green@dfci.harvard.edu
|
| Phone |
6175829074
|
| Organization name |
Dana-Farber Cancer Institute
|
| Department |
Medical Oncology
|
| Lab |
Shipp Lab
|
| Street address |
44 Binney Street
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02446 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6801 |
[GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array |
|
| Samples (48)
|
|
| Relations |
| BioProject |
PRJNA128875 |
Less...
More...