|
| Status |
Public on Sep 05, 2023 |
| Title |
Early microRNA responses in rodent liver mediated by furan exposure establish dose thresholds for later adverse outcomes |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
In this study, we evaluated the utility of microRNA (miRNA) profiling in female B6C3F1 mouse liver to indicate mechanisms of liver perturbation due to short-term exposure of the known rodent liver hepatotoxicant and carcinogen, furan. Analyses indicated a robust dose response for 34 miRNAs to furan and involvement of p53-linked pathways in furan-mediated hepatotoxicity. Overall, these results indicate mechanistic involvement of miRNA in furan carcinogenicity and provide evidence of their potential utility as accessible biomarkers of exposure and disease.
|
| |
|
| Overall design |
6–7-week-old female B6C3F1 mice were exposed by oral gavage to non-carcinogenic (0, 1 or 2 mg/kg bodyweight per day) or carcinogenic (4 or 8 mg/kg bodyweight per day) doses of furan in corn oil for 21 days.
|
| |
|
| Contributor(s) |
Chorley BN, Nelson GM, Carswell GK |
| Citation(s) |
37517673 |
| Submission date |
Jan 31, 2023 |
| Last update date |
Sep 05, 2023 |
| Contact name |
Brian Chorley |
| E-mail(s) |
chorley.brian@epa.gov
|
| Phone |
919-541-2329
|
| Organization name |
US EPA
|
| Street address |
US EPA, 109 TW Alexander Dr
|
| City |
Research Triangle Park |
| State/province |
NC |
| ZIP/Postal code |
27709 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16173 |
Illumina HiScanSQ (Mus musculus) |
|
| Samples (24)
|
|
| Relations |
| BioProject |
PRJNA930135 |
Less...
More...