|
| Status |
Public on Mar 19, 2024 |
| Title |
Effects of fasting on gene expression from livers with or without Mcl1 genetic deletion |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
MCL-1 is an essential pro-survival molecule of the BCL-2 family of proteins. Recent data, however, suggest it may play an as-yet unclarified role in mitochondrial metabolism.
Liver-specific deletion of MCL-1 followed by dietary stress leads to alteration of multiple genetic programs including fatty acid metabolic processes.
|
| |
|
| Overall design |
We used Affymetrix arrays to investigate the transcriptional changes that occur upon fasting in animals wherein MCL-1 has been deleted specifically in the liver.
|
| |
|
| Contributor(s) |
Turnis ME, Wang Y, Opferman JT |
| Citation(s) |
38503284 |
| Submission date |
Feb 10, 2023 |
| Last update date |
Mar 20, 2024 |
| Contact name |
Yong-Dong Wang |
| E-mail(s) |
michael.wang@stjude.org
|
| Phone |
9015954224
|
| Organization name |
St. Jude Children's Research Hospital
|
| Street address |
262 Danny Thomas Pl, MS1135
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38134 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
|
| Samples (20)
|
|
| Relations |
| BioProject |
PRJNA933619 |
Less...
More...