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| Status |
Public on Sep 14, 2023 |
| Title |
Lysine methylation of EHMT1/GLP as a molecular switch to reprogram transcription networks in prostate cancer [RNA-seq UNC0642] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Our studies provide novel molecular insights into the activity and function of EHMT1 during PCa progression and suggest a novel therapeutic strategy to treat CRPC with EHMT1 inhibitors.
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| Overall design |
LNCaP-tet-EHMT1 cells were treated with/out 0.5ug/mL docxycycline and 2uM UNC0642 for two days. LNCaP cells were treated with siNTC, SiEHMT2 at 20nM for two days. All RNA-seq samples contain replications.
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| Contributor(s) |
Besschetnova A, Han W, Liu M, Han D, Cai C |
| Citation(s) |
37663929 |
| Submission date |
Feb 10, 2023 |
| Last update date |
Sep 14, 2023 |
| Contact name |
Changmeng Cai |
| E-mail(s) |
changmeng.cai@umb.edu
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| Organization name |
University of Massachusetts Boston
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| Street address |
100 William T Morrissey Blvd
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02125 |
| Country |
USA |
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| Platforms (1) |
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| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE201771 |
Lysine methylation of EHMT1/GLP as a molecular switch to reprogram transcription networks in prostate cancer |
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| Relations |
| BioProject |
PRJNA933650 |
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