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| Status |
Public on Jul 17, 2010 |
| Title |
Expression data from MMP-8 wild type and KO mice with or without arthritis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Rheumatoid arthritis is an autoimmune disease in which joint inflammation lead to progressive cartilage and bone destruction. Matrix metalloproteinases (MMP) implicated in homeostasis of extracellular matrix (ECM) play a central role in cartilage degradation. The aim of this study was to investigate the role of MMP-8 (collagenase-2) suppression in the K/BxN serum-transfer arthritis model.
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| Overall design |
Three male mice of each following groups: MMP-8 wild type and arthritic mice, MMP-8 wild type without arthritis (wild type control), MMP-8 KO and arthritic mice and MMP-8 KO without arthritis (KO control) were selected for RNA extraction, from ankle joints, and hybridation on Affymetrix microarrays. Male mice were used because they showed a trend to higher arthritis severity compared to female mice. In arthritic mice, ankle joints were taken 7 days after arthritis induction.
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| Contributor(s) |
García S, Forteza J, López-Otin C, Gómez-Reino JJ, González A, Conde C |
| Citation(s) |
21190566 |
| Submission date |
Jul 16, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Carmen Conde |
| E-mail(s) |
carmen.conde.muro@sergas.es
|
| Phone |
34 981 950 903
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| Organization name |
Hospital Clinico Universitario
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| Lab |
Laboratorio de Investigacion nº 10
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| Street address |
Choupana s/n
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| City |
Santiago de Compostela |
| State/province |
A Coruña |
| ZIP/Postal code |
15706 |
| Country |
Spain |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA127747 |
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