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| Status |
Public on Dec 13, 2023 |
| Title |
DGCR8 promotes intestinal regeneration of damaged epithelium in a p53 signaling dependent manner |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
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| Summary |
TO explore role of DGCR8, a essential factor in canonical microRNAs biogenesis, in intestinal epithelial regeneration, we performed gene expression profiling analysis using data obtained from RNA-seq of intestinal organoids, intesitnal stem cells, and crypts from mice following 5-FU administration. To further investigate which microRNA was responsible for intestinal regeneration, we also performed small RNA sequencing with intestinal stem cells and intestinal epithelia cells.
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| Overall design |
Comparative transcriptome profiling analysis of RNA-seq data for intestinal stem cells, intestinal organoids, and crypts from mice following 5-FU administration.
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| Contributor(s) |
Wei X, Yu S, Chen Y |
| Citation(s) |
37939210 |
| Submission date |
Apr 20, 2023 |
| Last update date |
Dec 13, 2023 |
| Contact name |
Ye-Guang Chen |
| E-mail(s) |
ygchen@tsinghua.edu.cn
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| Phone |
86-020-32015300
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| Organization name |
Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences
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| Street address |
190 Kaiyuan Avenue, Guangzhou Science Park, Luogang District
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| City |
Guangzhou |
| ZIP/Postal code |
510530 |
| Country |
China |
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| Platforms (2) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
| GPL30215 |
MGISEQ-2000RS (Mus musculus) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA957780 |
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