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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 30, 2012 |
| Title |
Combinatorial effects of microRNA to suppress the myc oncogenic pathway |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
Expression profiling by array
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| Summary |
Many mammalian transcripts contain target sites for multiple miRNAs, although it is not clear to what extent miRNAs may coordinately regulate single genes. We have mapped the interactions between down-regulated miRNAs and overexpressed target protein-coding genes in murine and human lymphomas. Myc, one of the hallmark oncogenes in these lymphomas, stands out as the up-regulated gene with the highest number of genetic interactions with down-regulated miRNAs in mouse lymphomas. The regulation of Myc by several of these miRNAs is confirmed by cellular and reporter assays. The same approach identifies MYC and multiple Myc targets as a preferential target of down-regulated miRNAs in human Burkitt lymphoma, a pathology characterized by translocated MYC oncogenes. These results indicate that several miRNAs must be coordinately down-regulated to enhance critical oncogenes, such as Myc. Some of these Myc-targeting miRNAs are repressed by Myc, suggesting that these tumors are a consequence of the unbalanced activity of Myc versus miRNAs.
This SuperSeries is composed of the SubSeries listed below.
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| Overall design |
Refer to individual Series.
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| Contributor(s) |
Di Lisio L, Bueno MJ, Gómez-López G, Martínez N, Piris MA, Malumbres M |
| Citation(s) |
21478429 |
| Submission date |
Jul 20, 2010 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Lorena Di Lisio |
| E-mail(s) |
lorena.dilisio@libero.it
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| Organization name |
CNIO
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| Street address |
C/ Melchor Fernández Almagro, 3
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| City |
Madrid |
| ZIP/Postal code |
28029 |
| Country |
Spain |
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| Platforms (2) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
| GPL8617 |
Agilent-016436 Human miRNA Microarray (Probe Name version) |
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| Samples (48)
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| GSM729682 |
Burkitt Lymphoma4, miRNA |
| GSM729683 |
Burkitt Lymphoma5, miRNA |
| GSM729684 |
Burkitt Lymphoma6, miRNA |
| GSM729685 |
Burkitt Lymphoma7, miRNA |
| GSM729686 |
Burkitt Lymphoma8, miRNA |
| GSM729687 |
Burkitt Lymphoma9, miRNA |
| GSM729688 |
Burkitt Lymphoma10, miRNA |
| GSM729689 |
Burkitt Lymphoma11, miRNA |
| GSM729690 |
Burkitt Lymphoma12, miRNA |
| GSM729691 |
Tonsil1, miRNA |
| GSM729692 |
Tonsil2, miRNA |
| GSM729693 |
Tonsil3, miRNA |
| GSM729694 |
Tonsil4, miRNA |
| GSM729695 |
Lymph Node1, miRNA |
| GSM729696 |
Lymph Node2, miRNA |
| GSM729697 |
Lymph Node3, miRNA |
| GSM729698 |
Lymph Node4, miRNA |
| GSM729699 |
Lymph Node5, miRNA |
| GSM729700 |
Lymph Node6, miRNA |
| GSM729701 |
CD19+CD10+ cells1, miRNA |
| GSM729702 |
CD19+CD10+ cells2, miRNA |
| GSM729703 |
CD19+CD10+ cells3, miRNA |
| GSM729704 |
CD19+CD10+ cells4, miRNA |
| GSM729705 |
Burkitt Lymphoma1, mRNA |
| GSM729706 |
Burkitt Lymphoma2, mRNA |
| GSM729707 |
Burkitt Lymphoma3, mRNA |
| GSM729708 |
Burkitt Lymphoma4, mRNA |
| GSM729709 |
Burkitt Lymphoma5, mRNA |
| GSM729710 |
Burkitt Lymphoma6, mRNA |
| GSM729711 |
Tonsil1, mRNA |
| GSM729712 |
Tonsil2, mRNA |
| GSM729713 |
Tonsil3, mRNA |
| GSM729714 |
Tonsil4, mRNA |
| GSM729715 |
Tonsil5, mRNA |
| GSM729716 |
Fresh tonsil, mRNA |
| GSM729717 |
B Cells, mRNA |
| GSM729718 |
Lymph Node1, mRNA |
| GSM729719 |
Lymph Node2, mRNA |
| GSM729720 |
Lymph Node3, mRNA |
| GSM729721 |
Lymph Node4, mRNA |
| GSM729722 |
Lymph Node5, mRNA |
| GSM729723 |
Lymph Node6, mRNA |
| GSM729724 |
Lymph Node7, mRNA |
| GSM729725 |
CD19+CD10+ cells1, mRNA |
| GSM729726 |
CD19+CD10+ cells2, mRNA |
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| This SuperSeries is composed of the following SubSeries: |
| GSE29491 |
Combinatorial effects of microRNA to suppress the myc oncogenic pathway (miRNA data) |
| GSE29492 |
Combinatorial effects of microRNA to suppress the myc oncogenic pathway (mRNA data) |
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| Relations |
| BioProject |
PRJNA131185 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE23026_RAW.tar |
378.0 Mb |
(http)(custom) |
TAR (of TXT) |
| Raw data provided as supplementary file |
| Processed data included within Sample table |
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