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| Status |
Public on Aug 30, 2010 |
| Title |
Multiple chromosomal monosomies are characteristic of giant cell ependymoma |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
Giant cell ependymoma (GCE), a rare ependymoma subtype, was only recently recognised as a separate diagnostic entity with variations both in malignant potential and in course of disease. The pathogenetic mechanisms behind ependymomas remain unknown. Only one karyotyped GCE has so far been reported. We present the first genomic characterisation of a supratentorial GCE using G-band karyotyping, DNA ploidy analysis and array comparative genomic hybridisation (aCGH). The G-banded karyotype was hypodiploid with multiple monosomies, a feature present also in the previously published case and, hence, probably characteristic of these tumours. We could also analyse cytogenetically a subsequent recurrent tumour, phenotypically an anaplastic ependymoma, but exhibiting a pattern of monosomies largely similar to that found in the primary tumour, allowing a first insight into the genetic events involved also in disease progression.
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| Overall design |
2 tumour samples analysed with the control DNA (supplied by Agilent)
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| Contributor(s) |
Dahlback HS, Brandal P, Krossnes BK, Fric R, Meling TR, Meza-Zepeda LA, Danielsen HE, Heim S |
| Citation(s) |
21683982 |
| Submission date |
Jul 21, 2010 |
| Last update date |
Dec 06, 2012 |
| Contact name |
Hanne-Sofie S Dahlback |
| E-mail(s) |
h.s.s.dahlback@medisin.uio.no
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| Organization name |
The Norwegian Radium Hospital
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| Department |
Section for Cancer Cytogenetics
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| Street address |
Montebello
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| City |
Oslo |
| ZIP/Postal code |
0310 |
| Country |
Norway |
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| Platforms (1) |
| GPL10123 |
Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA129873 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE23065_RAW.tar |
99.9 Mb |
(http)(custom) |
TAR (of TXT, XLS) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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