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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jul 17, 2023 |
| Title |
Effect of WNT hyperactivation by CTNNB1 overexpression or APC knockdown on gene expression in HT29 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate effect of WNT hyperactivation by CTNNB1 overexpression or APC knockdown on gene expression and probe possible mechanism of cell viability effect, we overexpressed GFP/CTNNB1, or induce knockdown of APC by shNT1 (non-targeting) and shAPC
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| Overall design |
4 experimental conditions (GFP overexpression, CTNNB1 overexpression, shNT1 ctr, shRNA-APC), in triplicate, of human HT29 tumor cells.
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| Contributor(s) |
Chang L |
| Citation(s) |
37749246 |
| Submission date |
May 19, 2023 |
| Last update date |
Oct 16, 2023 |
| Contact name |
Sellers Lab |
| Organization name |
Broad Institute
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| Street address |
415 Main St
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| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02142 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA974459 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE232944_CTNNB1vGFP.limma_star.annot.csv.gz |
4.1 Mb |
(ftp)(http) |
CSV |
| GSE232944_STAR_Gene_TPM.csv.gz |
1.2 Mb |
(ftp)(http) |
CSV |
| GSE232944_shRNA-NT1vshRNA-APC.limma_star.annot.csv.gz |
4.1 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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