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Series GSE23611 Query DataSets for GSE23611
Status Public on Jan 18, 2011
Title Lung biopsies from asthmatics pre- and post- steroid treatment and from healthy control
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To better understand the therapeutic potential of targeting Th2 inflammation in asthma, we performed genome-wide expression profiling of endobronchial biopsies in asthmatics and healthy controls stratified according a previously defined three-gene Th2 signature in bronchial epithelium.
The Th2 signature is defined as relatively high expression of POSTN, CLCA1, and SERPINB2.
 
Overall design Endobronchial biopsies from 27 asthmatics and 13 healthy controls were assayed on expression microarrays. Biopsies were obtained from asthmatics before and one week after treatment with Flovent, an inhaled corticosteroid commonly used to treat asthma.
 
Contributor(s) Abbas AR, Choy DF, Modrek B, Kummerfeld S, Clark HF, Wu LC, Fedorowicz G, Modrusan Z, Fahy JV, Woodruff PG, Arron JR
Citation(s) 21187436
Submission date Aug 13, 2010
Last update date Nov 14, 2019
Contact name Alex Abbas
E-mail(s) abbas@gene.com
Organization name Genentech, Inc.
Department Bioinformatics
Street address 1 DNA Way
City South San Francisco
State/province CA
ZIP/Postal code 94080
Country USA
 
Platforms (1)
GPL6480 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)
Samples (62)
GSM578966 Lung_healthy (SRC119821)
GSM578967 Lung_healthy (SRC119812)
GSM578968 Lung_healthy (SRC119778)
Relations
BioProject PRJNA129953

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23611_RAW.tar 885.4 Mb (http)(custom) TAR (of TXT)
Processed data provided as supplementary file
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