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| Status |
Public on Jul 15, 2023 |
| Title |
Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To gain insight into the differential signaling pathways triggered in N-RAS-/- versus N-RAS+/+ mice during liver injury and fibrosis, we performed microarray analyses of livers 28 days after CCl4 treatment and BDL surgery, respectively. Our findings suggested that increased cell proliferation and matrix deposition as well as loss of cell homeostasis were characteristic of N-RAS-/- after experimental fibrosis.
We used microarrays to detail the global programme of gene expression underlying CCl4 and BDL challenge,
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| Overall design |
CCl4 and BDL induced gene expression in livers of N-RAS-/- and N-RAS+/+ mice was measured at 28 days after challenge. Three livers from each group were analyzed in both CCl4 and BDL experiments.
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/37563155/
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| Contributor(s) |
Cubero FJ, ZHENG K |
| Citation(s) |
37563155 |
| Submission date |
Jul 10, 2023 |
| Last update date |
Oct 24, 2023 |
| Contact name |
Francisco Javier Cubero |
| E-mail(s) |
fcubero@ucm.es
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| Organization name |
Complutense University School of Medicine
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| Department |
Department of Immunology, Ophthalmology & ENT
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| Street address |
c/Doctor Severo Ochoa, 9
|
| City |
Madrid |
| ZIP/Postal code |
28040 |
| Country |
Spain |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA993123 |
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