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| Status |
Public on Apr 23, 2024 |
| Title |
Dynamic Changes in Extracellular Vesicle-Associated miRNAs Elicited by Abdominal Ultrasound in Peripheral Blood of Inflammatory Bowel Disease Patients |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
Blood-based biomarkers that reliably indicate disease activity in the intestinal tract are an important unmet need in the management of patients with IBD. Extracellular vesicles (EVs) are cell-derived membranous microparticles, which reflect the cellular and functional state of their site of site of origin. As ultrasound waves may lead to an increased release of EVs, we hypothesized that application of ultrasound waves on inflamed intestinal tissue in IBD may amplify the release of tissue-specific EVs, which in turn can be detected in the peripheral blood.
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| Overall design |
26 patients with IBD were included in the prospective clinical study. Serum samples were collected before and 30 minutes after diagnostic transabdominal ultrasound. Differential miRNA expression was analyzed by sequencing.
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| Contributor(s) |
Mishra N, Baran N, Tran F, Rosenstiel P |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 21, 2023 |
| Last update date |
Apr 23, 2024 |
| Contact name |
Neha Mishra |
| E-mail(s) |
n.mishra@ikmb.uni-kiel.de
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| Organization name |
Institute of Clinical Molecular Biology
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| Lab |
Cell biology Lab
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| Street address |
Rosalind-Franklin-Str. 12
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| City |
Kiel |
| ZIP/Postal code |
24105 |
| Country |
Germany |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (52)
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| Relations |
| BioProject |
PRJNA997354 |
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