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Series GSE23933 Query DataSets for GSE23933
Status Public on Nov 15, 2011
Title human duodenum biopsy data
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium, and the microbiota. We found that mice lacking B lymphocytes, or lacking IgA, have low intestinal expression of lipid metabolism genes regulated by the transcription factor GATA4, and a consequent decrease in fat absorption in the intestine. The defect disappeared in germ free mice, suggesting that it is dependent on the microbiota; and sequencing analysis of the bacteria showed subtle differences between normal and B-cell deficient mice. Analysis of gene expression of gut biopsies from patients with common variable immunodeficiency and intestinal dysfunction revealed a high similarity to mouse B-cell knockout profiles. These data provide an explanation for a longstanding enigmatic association between immunodeficiency and defective lipid absorption in humans.
this series represents the subsection of the study where we analize gene epxression in duodenum biopsies from CVID patients and contols with unrelated pathologies
 
Overall design Reference sample is from normal duodenum (Clontech). Log2 ratio Cy5/Cy3 was used.
 
Contributor(s) Shulzhenko N, Morgun A
Citation(s) 22101768
Submission date Sep 01, 2010
Last update date Jan 23, 2019
Contact name Natalia Shulzhenko
E-mail(s) anemorgun@hotmail.com, shulzhenkon@niaid.nih.gov
Organization name NIAID, USA
Department Laboratory of Cellular and Molecular Immunology
Lab Ghost lab
Street address 9000 Rockville Pike
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
 
Platforms (1)
GPL6480 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)
Samples (6)
GSM589927 control1
GSM589928 control2
GSM589929 patient1
This SubSeries is part of SuperSeries:
GSE23934 Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut
Relations
BioProject PRJNA133205

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23933_RAW.tar 92.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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