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| Status |
Public on Aug 14, 2023 |
| Title |
Effects of CXCR2 knockdown in gastric granulocytic myeloid-derived suppressor cells (G-MDSCs) during chronic inflamation. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Myeloid-derived suppressor cells (MDSCs) comprise a hetergenous immune cell population that expands within the inflamed microenvironment of the stomach during pre-cancerous and cancerous lesion development in mouse.
This study compares gastric CD11b+Ly6G+ cells vetween Cxcr2flox/flox and S100A8CreCxcr2flox/flox after 6 month H. felis infection.
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| Overall design |
Two mice and two knockdown conditions for four samples and 2 biological replicates per genotype.
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| Contributor(s) |
Kai J, El-Zaatari M, Grasberger H |
| Citation(s) |
37744359 |
| Submission date |
Aug 11, 2023 |
| Last update date |
Sep 27, 2023 |
| Contact name |
Bioinformatics Core |
| E-mail(s) |
bioinformatics@umich.edu
|
| Organization name |
University of Michigan
|
| Street address |
BRCF Bioinformatics Core, 2800 Plymouth Rd
|
| City |
Ann Arbor |
| State/province |
Mi |
| ZIP/Postal code |
48109-2800 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17400 |
[MoGene-2_1-st] Affymetrix Mouse Gene 2.1 ST Array [transcript (gene) version] |
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| Samples (4)
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| GSM7708233 |
CD11b+Ly6G+ Cxcr2flox/flox + H. felis Mouse 1 |
| GSM7708234 |
CD11b+Ly6G+ Cxcr2flox/flox + H. felis Mouse 2 |
| GSM7708235 |
CD11b+Ly6G+ S100A8CreCxcr2flox/flox + H. felis Mouse 1 |
| GSM7708236 |
CD11b+Ly6G+ S100A8CreCxcr2flox/flox + H. felis Mouse 2 |
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| This SubSeries is part of SuperSeries: |
| GSE240720 |
The Cxcr2+ subset of the S100A8+ Gastric Granylocytic Myeloid-Derived Suppressor Cell Population Regulates Gastric Pathology |
|
| Relations |
| BioProject |
PRJNA1004664 |
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