|
| Status |
Public on Dec 01, 2010 |
| Title |
Epigenome analysis in HPV(-) and HPV(+) squamous cell carcinoma cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
|
| Summary |
Human papillomavirus (HPV)-associated head and neck cancers (HNSCCs) have a distinct risk profile and appreciate a prognostic advantage compared to HPV-negative HNSCC. Promoter hypermethylation has been widely recognized as an important mechanism in the progression of HNSCC, but the extent to which this mechanism is consistent between HPV(+) and HPV(-) tumors is unknown. To assess the genome-wide methylation changes in HPV(+) and HPV(-) tumors, we analyzed DNA methylation and expression patterns in two HPV(+) and two HPV(-) cell lines. HPV(+) tumors have overall higher DNA methylation in genic and LINE1 regions than HPV(-) tumors, and polycomb repressive complex 2 (PRC2) targets tend to be much more highly methylated in HPV(+) cells.
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| |
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| Overall design |
Bisulphite-converted DNA from 4 squamous cell carcinoma (SCC) cell lines were hybridized to the Illumina Infinium 27k Human Methylation Beadchip.
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| |
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| Contributor(s) |
Sartor MA, Dolinoy DC, Carey TE, Jones T, Colacino JA, Rozek LS |
| Citation(s) |
21613826 |
| Submission date |
Sep 12, 2010 |
| Last update date |
Jan 02, 2015 |
| Contact name |
Jung Kim |
| E-mail(s) |
junghk@umich.edu
|
| Organization name |
University of Michigan
|
| Street address |
1420 Washington Heights
|
| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48109 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL8490 |
Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2) |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE24091 |
Expression and methylation analyses of HPV(-) and HPV(+) squamous cell carcinoma cell lines |
|
| Relations |
| BioProject |
PRJNA133653 |
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