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| Status |
Public on Sep 19, 2023 |
| Title |
RNA-seq analysis for DMSO- or RSL3-treated H1299 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Ferroptosis suppresses tumor growth. Finding out potent pro-ferroptosis regulators via new approaches is extremely helpful for guiding and improving ferroptosis-based anti-tumor therapy. To seek pro-ferroptosis regulators, we proposed a novel screening strategy which focuses on molecules consistently upregulated even after long-time treatment of ferroptosis inducer. RNA-seq of RSL3-treated cells was performed as to be analysed together with RNA-seq data of ferroptosis-resistant cells in GEO dataset. Cysteine-rich angiogenic inducer 61 (CYR61) was identified as a novel pro-ferroptosis regulator via our new mining strategy.
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| Overall design |
The goal of this experiment was to characterize ferroptosis-related molecules.
RNA-seq of H1299 cells treated with DMSO or RSL3 for 24 h in three replicates
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| Contributor(s) |
Guo W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| BioProject |
PRJNA1013197 |
| Submission date |
Sep 12, 2023 |
| Last update date |
Sep 19, 2023 |
| Contact name |
Wanxin Guo |
| E-mail(s) |
wanda666@sjtu.edu.cn
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| Phone |
19121671932
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| Organization name |
Shanghai Chest Hospital
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| Street address |
West Huaihai Road No.241
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| City |
Shanghai |
| ZIP/Postal code |
200030 |
| Country |
China |
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| Platforms (1) |
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| Samples (6)
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| Supplementary file |
Size |
Download |
File type/resource |
| GSE242976_RNA-seq-proccessed.txt.gz |
59.3 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
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