|
| Status |
Public on Oct 02, 2010 |
| Title |
miRNA expression profile of human MALT lymphoma compared to gastritis and gDLBCL |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
To obtain global miRNA expression signatures of gDLBCL and its precursor lesions, total RNA isolated from 7-8 cases each of Helicobacter-associated reactive gastritis, low grade MALT lymphoma and high grade gDLBCL was hybridized to Agilent miRNA microarrays representing 795 human mature miRNAs. Unsupervised hierarchical clustering analysis revealed a clear segregation of the gDLBCL cases from the low grade MALT lymphomas and the gastritis samples; the segregation of the latter two disease entities was only incomplete (Figure 1A), reflecting the relative biological similarity of gastritis and low grade lymphomas. Statistical analysis of the dataset revealed only 26 differentially expressed miRNAs between these two groups (p<0.05), whereas 57 miRNAs exhibited significant differences in expression between low and high grade lymphomas.
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| Overall design |
7 human gastritis, 8 lowgrade MALT lymphoma and 7 high grade MALT lymphoma samples were used in the microarray analysis
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| Contributor(s) |
Craig VJ, Mueller A |
| Citation(s) |
21460242 |
| Submission date |
Oct 01, 2010 |
| Last update date |
May 07, 2014 |
| Contact name |
Vanessa Jane Craig |
| E-mail(s) |
craig@imcr.uzh.ch
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| Organization name |
Institute of molecular cancer research
|
| Street address |
Winterthurerstrasse 190
|
| City |
Zürich |
| ZIP/Postal code |
8057 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL8227 |
Agilent-019118 Human miRNA Microarray 2.0 G4470B (miRNA ID version) |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA132517 |
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