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| Status |
Public on Oct 23, 2010 |
| Title |
Gene expression data from cervical spinal cord regions of MPTP-intoxicated mouse by acupuncture |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
It has been shown that acupuncture at acupoints GB34 and LR3 inhibits the degeneration of nigrostriatal neurons in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease. This preventative effect of peripheral acupuncture stimulation is hypothesized to be transmitted through the spinal cord to the nigrostriatal neurons.
The gene expression profile changes following acupuncture at the acupoints were investigated in the cervical spinal cord of an MPTP-induced parkinsonism model using an Affymetrix genechip mouse gene 1.0 ST array.
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| Overall design |
C57BL/6 mice were divided into four experimental groups; ① C: Control, ② M: MPTP-treatment only, ③ MA: MPTP- and acupuncture-treatment at acupoints GB34 and LR3, ④ MNA: MPTP- and acupuncture-treatment at non-acupoints. Total RNA was isolated from the cervical spinal cord regions of each experimental group (4 experimental group × 2 samples of each experimental group = total 8 samples).
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| Contributor(s) |
Choi Y, Yeo S, Hong Y, Lim S |
| Citation(s) |
21440609 |
| Submission date |
Oct 20, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Sabina Lim |
| E-mail(s) |
lims@khu.ac.kr
|
| Phone |
82-2-961-0324
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| Organization name |
East-West Medical Research Institute, Kyung Hee University
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| Lab |
Research Group of Pain and Neuroscience
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| Street address |
#1 Hoegi-dong Dongdaemoon-gu
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| City |
Seoul |
| ZIP/Postal code |
130-701 |
| Country |
South Korea |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (8)
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| GSM611089 |
Control mouse 1 cervical spinal cord regions |
| GSM611090 |
Control mouse 2 cervical spinal cord regions |
| GSM611091 |
MPTP-treated mouse 1 cervical spinal cord regions |
| GSM611092 |
MPTP-treated mouse 2 cervical spinal cord regions |
| GSM611093 |
MPTP and acupoints acupuncture-treated mouse 1 cervical spinal cord regions |
| GSM611094 |
MPTP and acupoints acupuncture-treated mouse 2 cervical spinal cord regions |
| GSM611095 |
MPTP and nonacupoints acupuncture-treated mouse 1 cervical spinal cord regions |
| GSM611096 |
MPTP and nonacupoints acupuncture-treated mouse 2 cervical spinal cord regions |
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| This SubSeries is part of SuperSeries: |
| GSE24838 |
Gene expression data from brain striatal and spinal cord regions of MPTP-intoxicated mouse following acupuncture |
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| Relations |
| BioProject |
PRJNA133425 |
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