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| Status |
Public on Jan 11, 2024 |
| Title |
PDZ-Binding Kinase, a Novel Regulator of Vascular Remodeling in Pulmonary Arterial Hypertension |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the underlying mechanism of pulmonary hypertension, the model of monocrotaline (MCT)-treated pulmonary arterial hypertension (PAH) rats were constructed to detect the differentially expressed profile of genes in lung tissue of PAH rat.
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| Overall design |
The male rats were treated with monocrotaline (MCT) to induce pulmonary arterial hypertension model. One dose of MCT (60 mg/kg) was injected Intraperitoneally into animals. Control rats were injected with the equivalent volume of dissolvent solution according to their weights. After 4 weeks late, the lung tissue was collected to detect the genes expression profile.
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| Contributor(s) |
Huang H, Chen F, Fulton DR |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 04, 2024 |
| Last update date |
Jan 11, 2024 |
| Contact name |
Feng Chen |
| E-mail(s) |
fchen@njmu.edu.cn
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| Phone |
86 25 86862896
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| Organization name |
Nanjing Medical University
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| Department |
Department of forensic medicine
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| Lab |
Chen lab
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| Street address |
101 Longmian Ave
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| City |
Nanjing |
| State/province |
Jiangsu Province |
| ZIP/Postal code |
211166 |
| Country |
China |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1061191 |
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