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| Status |
Public on Feb 09, 2012 |
| Title |
Comparison of hepatic gene expression between short-term calorie restricted wild-type and Dgat1 deficient middle-aged female mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Leanness is associated with increased lifespan and is linked to favorable metabolic conditions promoting life extension.
We show here that deficiency of the lipid synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which reduces body fat in mice, promotes longevity. Female DGAT1-deficient mice were protected from age-related increases in body fat, non-adipose tissue triglycerides, and markers of inflammation in white adipose tissue. These metabolic changes were accompanied by an increased mean and maximal lifespan of ~25% and ~10%, respectively. The gene expression profile of DGAT1-deficient mice was not highly correlated with calorie restriction of sex and age matched wild-type littermates. Our findings indicate that loss of DGAT1-mediated lipid synthesis results in leanness, protects against age-related metabolic consequences, and thus extends longevity.
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| Overall design |
Liver gene expression profiles between short-term calorie restricted wild-type (WTCR) and Dgat1 deficient (KO) middle-aged (15-16 mo) female mice were compared to determine if calorie restriction and Dgat1 deficiency rely on common regulatory pathways for the promotion of longevity. Both CR and KO were compared to middle-aged wild-type female littermates fed a standard chow diet ad libitum (WTAL).
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| Contributor(s) |
Grueter CA, Farese RV |
| Citation(s) |
22291164 |
| Submission date |
Dec 22, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Nathan Salomonis |
| E-mail(s) |
nathan.salomonis@cchmc.org
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| Organization name |
Cincinnati Children's Hospital
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| Department |
Biomedical Informatics
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| Lab |
Nathan Salomonis
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| Street address |
3333 Burnet Avenue
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| City |
Cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45229 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (9)
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| GSM645108 |
Wild-type, caloric restriction diet rep1 |
| GSM645109 |
Wild-type, caloric restriction diet rep2 |
| GSM645110 |
Wild-type, caloric restriction diet rep3 |
| GSM645111 |
Dgat1-/-, ad libitum diet rep1 |
| GSM645112 |
Dgat1-/-, ad libitum diet rep2 |
| GSM645113 |
Dgat1-/-, ad libitum diet rep3 |
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| Relations |
| BioProject |
PRJNA134961 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE26267_RAW.tar |
36.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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