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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 01, 2024 |
| Title |
Aged skin exacerbates experimental osteoarthritis via enhanced IL-36R signaling |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate skin aging is an important driver of experimental osteoarthritis(OA) progression in mice via enhanced IL-36 receptor (IL-36R) signaling. The supernatants from the co-culture of UV-aged mouse primary keratinocytes with synovial fibroblasts were collected to induce mouse primary articular chondrocytes (CCs) to become aging SNL CCs. On this basis, Spesolimab (100ng/ml) was added to culture aging SNL CCs to study the drug's effect on OA. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 groups: control CCs, aging SNL CCs, aging SNL CCs+Spesolimab.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for control CCs, aging SNL CCs and aging SNL CCs+Spesolimab.
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| Contributor(s) |
Chen D, Wang C, Yang C, Chen L, Yang P, Zou Z, Li H, Xiao Y, Wu J, Cheng Q, Yang C, Ke E, Huang B, Bai X, Li K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 16, 2024 |
| Last update date |
May 01, 2024 |
| Contact name |
Dalin Chen |
| E-mail(s) |
dalincc@smu.edu.cn
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| Organization name |
Guangdong Institute of Orthopedics
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| Street address |
295 Changxing Road
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| City |
Guangzhou |
| ZIP/Postal code |
510000 |
| Country |
China |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1100990 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE264103_gene.xls.gz |
1.1 Mb |
(ftp)(http) |
XLS |
SRA Run Selector |
| Raw data are available in SRA |
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