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| Status |
Public on Sep 26, 2011 |
| Title |
Gene expression profile of SYT-SSX2-expressing human bone marrow-derived mesenchymal stem cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Synovial sarcoma is a rare malignancy characterized by the presence of a specific chromosomal translocation t(X;18) that results in the formation of a fusion protein SYT-SSX.
Because it is believed that synovial sarcoma arises from mesenchymal stem or progenitor cells, we used human bone marrow-derived mesenchymal stem cells (MSCs) to determine the changes in gene expression caused by this oncogene in untransformed MSCs.
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| Overall design |
In 2 independent experiments, human bone marrow-derived MSCs were infected with retrovirus carrying either control vector (pOZ) or SYT-SSX2 expression vector. Total cellular RNA was extracted 4 days post-infection and utilized for microarray analysis on Affymetrix arrays.
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| Contributor(s) |
Garcia CB, Eid JE |
| Citation(s) |
21996728, 22594313 |
| Submission date |
Jan 11, 2011 |
| Last update date |
Aug 14, 2019 |
| Contact name |
Josiane Eid |
| E-mail(s) |
josiane.eid@vanderbilt.edu
|
| Organization name |
Vanderbilt University
|
| Street address |
2220 Pierce Avenue
|
| City |
Nashville |
| ZIP/Postal code |
37232 |
| Country |
USA |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE26565 |
Reprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT-SSX2 |
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| Relations |
| BioProject |
PRJNA142227 |
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